Junping Jing
GlaxoSmithKline R&D, USA
Title: Explore cancer genomic databases to support immuno-oncology drug discovery
Biography
Biography: Junping Jing
Abstract
Cancer genomic databases such as The Cancer Genome Atlas (TCGA) have become invaluable knowledgebases for cancer drug discover. Besides providing comprehensive genomic and genetic properties of cancer cells in a tumor, they also shed light on the profiles and distribution of tumor infiltriting lymphocytes (TILs) in the tumor micro-environment. Using markers uniqulely representing different lymphocytes such as cytotoxic and regulatory T cells, we have characterized the TIL districution of ~10,000 primary tumors from 30 different cancer types. The talk will provide concrete examples how we are using this anlaysis to identify novel targets, discover biomarkers and stratify patients.
