Ravi Radhakrishnan
University of Pennsylvania, USA
Title: In silico oncology: Computational horizons in cancer systems biology and multiscale cancer modeling
Biography
Biography: Ravi Radhakrishnan
Abstract
We have developed a multi scale platform for the predictions of the effects of mutations on oncogene activation through a combination of molecular, biophysical and cellular models. We have combined the specificity of molecular modeling with the power of network models to predict the molecular mechanisms that lead to the activation of pathways. We have also employ spatial and stochastic models to describe how the effects of the tumor microenvironment can lead to oncogenic signals through non-canonical pathways. We will describe the applications of these models in the clinical contexts of non small cell lung cancer, neuroblastoma and hepatocellular carcinoma.
